Systems metabolic engineering: Genome-scale models and beyond
نویسندگان
چکیده
منابع مشابه
Building and analysing genome-scale metabolic models.
Reconstructing a model of the metabolic network of an organism from its annotated genome sequence would seem, at first sight, to be one of the most straightforward tasks in functional genomics, even if the various data sources required were never designed with this application in mind. The number of genome-scale metabolic models is, however, lagging far behind the number of sequenced genomes an...
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The Metabolic Models Reconstruction Using Genome-Scale Information (merlin) tool is a user-friendly Java application that aids the reconstruction of genome-scale metabolic models for any organism that has its genome sequenced. It performs the major steps of the reconstruction process, including the functional genomic annotation of the whole genome and subsequent construction of the portfolio of...
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Background: A genome-scale metabolic network model (GEM) is a mathematical representation of an organism’s metabolism. Today, GEMs are popular tools for computationally simulating the biotechnological processes and for predicting biochemical properties of (engineered) strains.Objectives: In the present study, we have evaluated the predictive power of two ...
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2 Genome-scale metabolic models have proven to be crucial resources for translating detailed knowledge of thousands of distinct biochemical processes into global predictions of organism behavior. These models can be used to predict essential genes, organism phenotypes, organism response to mutations, and metabolic engineering strategies [1]. The models also serve as platforms for assessing and ...
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Genome-scale metabolic models (GEMs) have become a popular tool for systems biology, and they have been used in many fields such as industrial biotechnology and systems medicine. Since more and more studies are being conducted using GEMs, they have recently received considerable attention. In this review, we introduce the basic concept of GEMs and provide an overview of their applications in bi...
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ژورنال
عنوان ژورنال: Biotechnology Journal
سال: 2010
ISSN: 1860-6768
DOI: 10.1002/biot.200900247